Symbol
Name
ID

Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes	Hereditary nonpolyposis colorectal carcinoma	Colon cancer	Intestinal pseudo-obstruction	Neoplasm of the stomach	Intermittent diarrhea	Nausea and vomiting	Functional intestinal obstruction	Neoplasm of the liver
Disease(s) Associated with TCF7L2	Hereditary nonpolyposis colorectal carcinoma	Colon cancer	Intestinal pseudo-obstruction	Neoplasm of the stomach	Intermittent diarrhea	Nausea and vomiting	Functional intestinal obstruction	Neoplasm of the liver
colorectal cancer
pancreatic cancer

Mouse Phenotypes

abnormal intestinal goblet cell morphology

abnormal colon goblet cell morphology

abnormal small intestine goblet cell morphology

increased enterocyte apoptosis

abnormal enterocyte proliferation

abnormal cecum position

abnormal intestine development

abnormal intestinal enteroendocrine cell morphology

abnormal intestine morphology

abnormal intestinal epithelium morphology

abnormal enterocyte morphology

decreased enterocyte cell number

abnormal crypts of Lieberkuhn morphology

decreased Paneth cell number

absent Paneth cells

ectopic Paneth cells

abnormal colon morphology

abnormal small intestine morphology

increased susceptibility to induced colitis

Availability

Mouse Genotype

Tcf7l2^m1Btlr/Tcf7l2^m1Btlr

Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^{tm1.1(EGFP/cre)Mrc}

Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2^{tm1a(EUCOMM)Wtsi}

Tcf7l2^tm1Cle/Tcf7l2^tm1Cle

Tcf7l2^tm2.2Mrc/Tcf7l2^tm2.2Mrc

Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0 (conditional)

Tcf7l2^{tm1(EGFP/cre)Mrc}/Tcf7l2^tm2.1Mrc (conditional)

Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.1Mrc (conditional)

Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.2Mrc (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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